Aberrant ADAM10 expression correlates with osteosarcoma progression.

ABSTRACT:

Background

Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated. Previous studies have shown that the expression of CD31 was significantly elevated in metastatic osteosarcoma; however, its expression in nonmetastatic groups is not known. In addition, the mysterious multinucleated giant cell in giant cell-rich osteosarcoma was previously regarded as an osteoclast-like cell, but its exact identity is unclear.

Method

Tissue chip samples from 40 cases of nonmetastatic osteosarcoma were stained for cytoplasmic

SUBMITTER: Zhao R 

PROVIDER: S-EPMC3936952 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature