The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome.

ABSTRACT:

Background

For the anucleate platelet it has been unclear how well platelet transcriptomes correlate among different donors or across different RNA profiling platforms, and what the transcriptomes' relationship is with the platelet proteome. We profiled the platelet transcriptome of 10 healthy young males (5 white and 5 black) with no notable clinical history using RNA sequencing and by Affymetrix microarray.

Results

We found that the abundance of platelet mRNA transcripts was highly correlated across the 10 individuals, independently of race and of the employed technology. Our RNA-seq data showed that these high inter-individual correlations extend beyond mRNAs to several categories of non-coding RNAs. Pseudogenes represented a notable exception by exhibiting a difference i

SUBMITTER: Londin ER 

PROVIDER: S-EPMC3937023 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature