Wiring the retinal circuits activated by light during early development.

ABSTRACT:

Background

Light information is sorted by neuronal circuits to generate image-forming (IF) (interpretation and tracking of visual objects and patterns) and non-image-forming (NIF) tasks. Among the NIF tasks, photic entrainment of circadian rhythms, the pupillary light reflex, and sleep are all associated with physiological responses, mediated mainly by a small group of melanopsin-expressing retinal ganglion cells (mRGCs). Using Xenopus laevis as a model system, and analyzing the c-fos expression induced by light as a surrogate marker of neural activity, we aimed to establish the developmental time at which the cells participating in both systems come on-line in the retina.

Results

We found that the peripheral retina contains 80% of the two melanopsin-expressing cell types we

SUBMITTER: Bertolesi GE 

PROVIDER: S-EPMC3937046 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature