Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection.

ABSTRACT: One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes immune mice to investigate whether bystander memory T cells influence Leishmania major infection. Despite similar parasite burdens, LCMV and Listeria immune mice exhibited a significant increase in leishmanial lesion size compared to mice infected with L. major alone. This increased lesion size was due to a severe inflammatory response, consisting not only of monocytes and neutrophils, but also significantly more CD8 T cells. Many o

SUBMITTER: Crosby EJ 

PROVIDER: S-EPMC3937277 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature