Ontology highlight
ABSTRACT:
SUBMITTER: Lehnertz B
PROVIDER: S-EPMC3937511 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Genes & development 20140201 4
Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological inhibition. Here we establish the histone methyltransferase G9a/EHMT2 as a selective regulator of fast proliferating myeloid progenitors with no discernible function in hematopoietic stem cells (HSCs). In mouse models of acute myeloid leukemia (AML), loss of G9a significantly delays disease progression and reduces leukemia stem cell (LSC) frequen ...[more]