Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.

ABSTRACT: The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other organs, relatively little is known about the molecular machinery that directly governs metabolic plasticity in the heart. Although previous studies have defined Kruppel-like factor 15 (KLF15) as a transcriptional repressor of pathologic cardiac hypertrophy, a direct role for the KLF family in cardiac metabolism has not been previously established. We show in human heart samples that KLF15 is induced after birth and reduced in heart failure, a myocardial expression pattern that parallels reliance on lipid oxidation. Isolated working heart studies and unbiased trans

SUBMITTER: Prosdocimo DA 

PROVIDER: S-EPMC3937660 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature