Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer.

ABSTRACT:

Objective

Homeobox B9 (HOXB9) is proposed to be involved in tumor angiogenesis and metastasis. We investigated the role of HOXB9 in the progression of colon cancer.

Methods

HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the patients. The effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in vivo.

Results

HOXB9 is overexpressed in colon cancer tissues and significantly correlated with metastasis and poor survival of patients (P<0.05, respectively). Additionally, high levels of expression of HOXB9 were observed in metastatic lymph nodes. The down-regulation of HOXB9 expression

SUBMITTER: Huang K 

PROVIDER: S-EPMC3937747 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature