Synthesis of QS-21-based immunoadjuvants.

ABSTRACT: Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) open the door to the pursuit of a new series of structurally defined QS-saponin-based synthetic adjuvants.

SUBMITTER: Wang P 

PROVIDER: S-EPMC3937867 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature