Genomic characterization of a Helicobacter pylori isolate from a patient with gastric cancer in China.

ABSTRACT:

Background

Helicobacter pylori is well known for its relationship with the occurrence of several severe gastric diseases. The mechanisms of pathogenesis triggered by H. pylori are less well known. In this study, we report the genome sequence and genomic characterizations of H. pylori strain HLJ039 that was isolated from a patient with gastric cancer in the Chinese province of Heilongjiang, where there is a high incidence of gastric cancer. To investigate potential genomic features that may be involved in pathogenesis of carcinoma, the genome was compared to three previously sequenced genomes in this area.

Result

We obtained 42 contigs with a total length of 1,611,192 bp and predicted 1,687 coding sequences. Compared to strains isolated from gastritis and ulcers in this area,

SUBMITTER: You Y 

PROVIDER: S-EPMC3938082 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature