The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma.

ABSTRACT:

Background

Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As functionally important intragenic copy number aberrations (iCNA) and fusion genes begin to be identified in adult HGG, the same has not yet been done in the childhood setting. We applied an iCNA algorithm to our previously published dataset of DNA copy number profiling in pHGG with a view to identify novel intragenic breakpoints.

Results

We report a series of 288 iCNA events in pHGG, with the presence of intragenic breakpoints itself a negative prognostic factor. We identified an increased number of iCNA in older children compared to infants, and increased iCNA in H3

SUBMITTER: Carvalho D 

PROVIDER: S-EPMC3938307 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature