Targeting of white matter tracts with transcranial magnetic stimulation.

ABSTRACT:

Background

TMS activations of white matter depend not only on the distance from the coil, but also on the orientation of the axons relative to the TMS-induced electric field, and especially on axonal bends that create strong local field gradient maxima. Therefore, tractography contains potentially useful information for TMS targeting.

Objective/methods

Here, we utilized 1-mm resolution diffusion and structural T1-weighted MRI to construct large-scale tractography models, and localized TMS white matter activations in motor cortex using electromagnetic forward modeling in a boundary element model (BEM).

Results

As expected, in sulcal walls, pyramidal cell axonal bends created preferred sites of activation that were not found in gyral crowns. The model agreed with the we

SUBMITTER: Nummenmaa A 

PROVIDER: S-EPMC3938327 | biostudies-literature | 2014 Jan-Feb

REPOSITORIES: biostudies-literature