Effect of lung volume on airway luminal area assessed by computed tomography in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Although airway luminal area (Ai) is affected by lung volume (LV), how is not precisely understood. We hypothesized that the effect of LV on Ai would differ by airway generation, lung lobe, and chronic obstructive pulmonary disease (COPD) severity.

Methods

Sixty-seven subjects (15 at risk, 18, 20, and 14 for COPD stages 1, 2, and 3) underwent pulmonary function tests and computed tomography scans at full inspiration and expiration (at functional residual capacity). LV and eight selected identical airways were measured in the right lung. Ai was measured at the mid-portion of the 3(rd), the segmental bronchus, to 6(th) generation of the airways, leading to 32 measurements per subject.

Results

The ratio of expiratory to inspiratory LV (LV E/I ratio) and Ai (Ai

SUBMITTER: Kambara K 

PROVIDER: S-EPMC3938549 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature