Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis.

ABSTRACT:

Background

Perinatal arterial ischemic stroke (AIS) occurs in an estimated 17 to 93 per 100000 live births, yet the etiology is poorly understood. Although investigators have implicated hypoxia as a potential cause of AIS, the role of hypoxia in AIS remains controversial. The aim of this study was to estimate the association between perinatal hypoxia factors and perinatal arterial ischemic stroke through a meta-analysis of published observational studies.

Patients and methods

A systematic search of electronically available studies published through July 2013 was conducted. Publication bias and heterogeneity across studies were evaluated and summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with fixed-effects or random-effects models.

Results

SUBMITTER: Luo L 

PROVIDER: S-EPMC3938587 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature