Transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression.

ABSTRACT:

Background

Although the most common clinical presentation of multiple sclerosis (MS) is the so called Relapsing-Remitting MS (RRMS), the molecular mechanisms responsible for its progression are currently unknown. To tackle this problem, a whole-genome gene expression analysis has been performed on RRMS patients.

Results

The comparative analysis of the Affymetrix Human Gene 1.0 ST microarray data from peripheral blood leucocytes obtained from 25 patients in remission and relapse and 25 healthy subjects has revealed 174 genes altered in both remission and relapse, a high proportion of them showing what we have called "mirror pattern": they are upregulated in remission and downregulated in relapse or vice versa. The coexpression analysis of these genes has shown that they are o

SUBMITTER: Irizar H 

PROVIDER: S-EPMC3938749 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature