Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer.

ABSTRACT:

Background

High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expression in EOC.

Methods

After an initial screening in the Human Protein Atlas portal, a validated antibody was selected for extended analysis of immunohistochemical PIGR expression in tissue microarrays with tumours from 154 incident cases of EOC from two pooled prospective population-based cohorts. Subsets of corresponding benign-appearing fallopian tubes (n = 38) and omental metasta

SUBMITTER: Berntsson J 

PROVIDER: S-EPMC3938822 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature