Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy.

ABSTRACT: We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

SUBMITTER: Suntharalingam K 

PROVIDER: S-EPMC3938893 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature