Management of the HBV reactivation in isolated HBcAb positive patients affected with Non Hodgkin Lymphoma.

ABSTRACT:

Background

Occult HBV infection (OBI) is defined by the persistence of HBV in the liver without serum HBsAg and HBVDNA. It represents a life-threatening event during immunosuppressive chemotherapies. An OBI occurs in approximately 18% of HBcAb + patients. International guidelines suggest surveillance for HBV markers in immunosuppressed patients. In Non-Hodgkin Lymphoma (NHL), the prevalence of OBI reactivation remains to be established.

Methods

In order to determine the prevalence of occult HBV reactivation in a large cohort of patients during chemotherapy for NHL, we analysed 498 NHL patients in a centre of Southern Italy. We evaluated HBV markers, NHL type, treatment type and occurrence of HBV reactivation.

Results

Forty % of patients were treated with monoclonal an

SUBMITTER: Masarone M 

PROVIDER: S-EPMC3938973 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature