A genome-wide association study of bronchodilator response in Latinos implicates rare variants.

ABSTRACT:

Background

The primary rescue medication to treat acute asthma exacerbation is the short-acting β₂-adrenergic receptor agonist; however, there is variation in how well a patient responds to treatment. Although these differences might be due to environmental factors, there is mounting evidence for a genetic contribution to variability in bronchodilator response (BDR).

Objective

To identify genetic variation associated with bronchodilator drug response in Latino children with asthma.

Methods

We performed a genome-wide association study (GWAS) for BDR in 1782 Latino children with asthma using standard linear regression, adjusting for genetic ancestry and ethnicity, and performed replication studies in an additional 531 Latinos. We also performed admixture mapping across

SUBMITTER: Drake KA 

PROVIDER: S-EPMC3938989 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature