Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China.

ABSTRACT:

Objectives

Genetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB pathway gene polymorphisms and susceptibility of liver cancer. The aim of this study was to investigate whether genetic variants of NFKB1 and NFKBIA were associated with risk of liver cancer in a Chinese population.

Design

The study was designed as a nested case-control study within two prospective cohorts (the Shanghai Women's Health Study, SWHS, 1996-2000 and the Shanghai Men's Health Study, SMHS, 2002-2006).

Settings

This population-based study was conducted in urban Shanghai, China.

Participants

A total of 217 incident liver cancer cases diagnosed through 31 Decemb

SUBMITTER: Gao J 

PROVIDER: S-EPMC3939648 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature