Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy.

ABSTRACT: Obesity has profound negative consequences on female reproduction as well as on the metabolic health of offspring. Bariatric surgery is the most effective method for sustained weight loss. A critical question is whether bariatric surgery can reverse the deleterious effects of obesity on both female reproduction and subsequent offspring. Vertical sleeve gastrectomy (VSG) is a bariatric procedure rapidly growing in popularity because it provides weight loss and other metabolic benefits that are comparable to those offered by the more complicated Roux-en-Y gastric bypass (RYGB). Female rats rendered obese on a high-fat diet (HFD) underwent either VSG or sham surgery. Like their male counterparts, females had significant metabolic improvements including reduced adiposity and improved glucose t

SUBMITTER: Grayson BE 

PROVIDER: S-EPMC3939702 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature