Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution.

ABSTRACT:

Background

Ambient particles are associated with cardiovascular events and recently with total plasma homocysteine. High total plasma homocysteine is a risk for human health. However, the biologic mechanisms are not fully understood. One of the putative pathways is through oxidative stress. We aimed to examine whether associations of PM2.5 and black carbon with homocysteine were modified by genotypes including HFE H63D, C282Y, CAT (rs480575, rs1001179, rs2284367, and rs2300181), NQO1 (rs1800566), GSTP1 I105V, GSTM1, GSTT1 (deletion vs. nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature.

Methods

Study subjects were 1000 white non-Hispanic men i

SUBMITTER: Ren C 

PROVIDER: S-EPMC3939788 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature