Modeling of chemical inhibition from amyloid protein aggregation kinetics.

ABSTRACT:

Backgrounds

The process of amyloid proteins aggregation causes several human neuropathologies. In some cases, e.g. fibrillar deposits of insulin, the problems are generated in the processes of production and purification of protein and in the pump devices or injectable preparations for diabetics. Experimental kinetics and adequate modelling of chemical inhibition from amyloid aggregation are of practical importance in order to study the viable processing, formulation and storage as well as to predict and optimize the best conditions to reduce the effect of protein nucleation.

Results

In this manuscript, experimental data of insulin, Aβ42 amyloid protein and apomyoglobin fibrillation from recent bibliography were selected to evaluate the capability of a bivariate sigmoid equa

SUBMITTER: Vazquez JA 

PROVIDER: S-EPMC3939820 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature