Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.

ABSTRACT: We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-grade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed "luminal" and "basal-like," which have characteristics of different stages of urothelial differentiation, reflect the luminal and basal-like molecular subtypes of breast cancer, and have clinically meaningful differences in outcome. A gene set predictor, bladder cancer analysis of subtypes by gene expression (BASE47) was defined by prediction analysis of microarrays (PAM) and accurately classifies the subtypes. Our data demonstrate that there are at least two molecularly and clinically distinct s

SUBMITTER: Damrauer JS 

PROVIDER: S-EPMC3939870 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature