Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder.

ABSTRACT: Posttraumatic stress disorder (PTSD) is a common condition induced by life-threatening stress, such as that experienced by soldiers under battlefield conditions. Other than the commonly recognized behavioral and psychological dysfunction, epidemiological studies have also revealed that PTSD patients have a higher risk of other diseases, such as cardiovascular disorders. Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation. Our results revealed acute heart injury associated with the traumatic experience, reflecting the underlying biological injury processes of the immune response, extracellular matrix remodeling, epithelial-to-mesenchymal cell transitions, and cell proliferation. Whether this typ

SUBMITTER: Cho JH 

PROVIDER: S-EPMC3939897 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature