Statin therapy as prevention against development of acute respiratory distress syndrome: an observational study.

ABSTRACT:

Objectives

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors ("statins") have anti-inflammatory properties and are associated with improved outcomes in critically ill patients. We investigated whether previous statin therapy affects outcomes in patients at risk for acute respiratory distress syndrome.

Design

Patients were followed-up for the primary outcome of acute respiratory distress syndrome and secondary outcomes of intensive care unit and 60-day mortality, organ dysfunction, and ventilator-free days in a secondary analysis of a prospective cohort study. Receipt of statin therapy was recorded. Propensity score matching was used to adjust for confounding by indication.

Setting

Intensive care units at a tertiary care academic medical center.

Patient

SUBMITTER: Bajwa EK 

PROVIDER: S-EPMC3939937 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature