Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine.

ABSTRACT:

Objective

CYP2B6 variation predicts pharmacokinetic characteristics of its substrates. Consideration for underlying genetic structure is critical to protect against spurious associations with the highly polymorphic CYP2B6 gene.

Design

The effect of CYP2B6 variation on response to its substrates, nonnucleoside reverse transcriptase inhibitors (NNRTIs), was explored in the Women's Interagency HIV Study.

Methods

Five putative functional polymorphisms were tested for associations with virologic suppression within 1 year after NNRTI initiation in women naive to antiretroviral agents (n = 91). Principal components were generated to control for population substructure. Logistic regression was used to test the joint effect of rs3745274 and rs28399499, which together indicate

SUBMITTER: Frasco MA 

PROVIDER: S-EPMC3940150 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature