Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach.

ABSTRACT:

Background

Depressive patients often have altered cortisol secretion, but few studies have investigated genetic variants in relation to both cortisol secretion and depression. To identify genes related to both these conditions, we: (1) tested the association of single nucleotide polymorphisms (SNPs) in hypothalamic-pituitary-adrenal-axis (HPA-axis) candidate genes with a summary measure of total cortisol secretion during the day (cortisol(AUC)), (2) performed a genome wide association study (GWAS) of cortisol(AUC), and (3) tested the association of identified cortisol-related SNPs with depressive symptoms.

Methods

We analyzed data on candidate SNPs for the HPA-axis, genome-wide scans, cortisol secretion (n=1711) and depressive symptoms (the Centre for Epidemiology Studies De

SUBMITTER: Velders FP 

PROVIDER: S-EPMC3940151 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature