Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management.

ABSTRACT: Development of idiosyncratic hepatotoxicity is an intricate process involving both concurrent as well as sequential events determining the direction of the pathways, degree of liver injury and its outcome. Decades of clinical observation have identified a number of drug and host related factors that are associated with an increased risk of antituberculous drug-induced hepatotoxicity, although majority of the studies are retrospective with varied case definitions and sample sizes. Investigations on genetic susceptibility to hepatotoxicity have so far focused on formation and accumulation reactive metabolite as well as factors that contribute to cellular antioxidant defense mechanisms and the environment which can modulate the threshold for hepatocyte death secondary to oxidative stress. Rec

SUBMITTER: Ramappa V 

PROVIDER: S-EPMC3940184 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature