Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3940256 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction.
Yang Yong Y Shen Jianliang J Yu Xujiang X Qin Guoting G Zhang Mingzhen M Shen Haifa H Mao Zongwan Z Ferrari Mauro M
Chembiochem : a European journal of chemical biology 20130429 8
Using single-molecule force measurement and fluorescence imaging, we have demonstrated that luteolin has an inhibitory effect on IGF-1 ligand-receptor binding, the initial step in IGF-1 signaling. This inhibition mechanism, which was confirmed by flow cytometry and molecular docking, could play a role in cancer therapy. ...[more]
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