Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometry.

ABSTRACT:

Background

Gray and white matter volume deficits have been reported in many structural magnetic resonance imaging (MRI) studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural MRI studies of adults with ADHD. This study used voxel based morphometry and applied an a priori region of interest approach based on our previous work, as well as from well-developed neuroanatomical theories of ADHD.

Methods

Seventy-four adults with DSM-IV ADHD and 54 healthy control subjects comparable on age, sex, race, handedness, IQ, reading achievement, frequency of learning disabilities, and whole brain volume had an MRI on a 1.5T Siemens scanner. A priori region of interest hypotheses focused on reduced volumes in ADHD in dorsolateral

SUBMITTER: Seidman LJ 

PROVIDER: S-EPMC3940267 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature