The increasing genetic diversity of HIV-1 in the UK, 2002-2010.

ABSTRACT:

Objective

HIV-1 is typically categorized by genetically distinct viral subtypes. Viral subtypes are usually compartmentalized by ethnicity and transmission group and, thus, convey important epidemiological information, as well as possibly influencing the rate of disease progression. We aim to describe the prevalence and time trends of subtypes observed among key populations living with HIV-1 in the UK.

Design

Analyses of reverse transcriptase and protease sequences generated from HIV-1-positive antiretroviral-naive patients as part of routine resistance testing between 2002 and 2010 in all public health and NHS laboratories in the UK.

Methods

Subtype was assigned centrally using the SCUEAL algorithm. Subtyping results were combined with data from the UK Collaborative

SUBMITTER: UK Collaborative Group on HIV Drug Resistance 

PROVIDER: S-EPMC3940288 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature