The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.

ABSTRACT: Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the

SUBMITTER: Valentini A 

PROVIDER: S-EPMC3940343 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature