Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer.

ABSTRACT:

Purpose

The mismatch repair system is a DNA repair mechanism that corrects mispaired bases during DNA replication errors. Cancer cells deficient in MMR proteins have a 10(2) to 10(3)-fold increase in the mutation rate. Single nucleotide polymorphisms of mismatch repair genes have been shown to cause a decrease in DNA repair activity. We hypothesized that mismatch repair gene polymorphism could be a risk factor for prostate cancer and p53 Pro/Pro genotype carriers could influence MSH3 and MSH6 polymorphisms.

Materials and methods

DNA samples from 110 patients with prostate cancer and 110 healthy controls were analyzed by single strand conformational polymorphism and polymerase chain reaction-restriction fragment length polymorphism to determine the genotypic frequency of 5 po

SUBMITTER: Hirata H 

PROVIDER: S-EPMC3940351 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature