Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer.

ABSTRACT: Bladder cancer is often associated with recurrence and progression to invasive metastatic disease that have palliative therapeutic options. The use of traditional chemotherapeutic agents for bladder cancer management often suffers from toxicity and resistance concerns. This emphasizes the need for development of safer, natural, nontoxic compounds as chemotherapeutic/chemopreventive agents. Curcumin (diferuloylmethane) is a natural compound that has been known to possess anticancer properties in various cancers, including bladder cancer. However, the biological targets of curcumin are not well defined. Recently, it has been proposed that curcumin may mediate epigenetic modulation of expression of microRNAs (miRNA). In this article, we define for the first time, that curcumin directly induce

SUBMITTER: Saini S 

PROVIDER: S-EPMC3940389 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature