Angiotensin II receptor blockers improve peripheral endothelial function: a meta-analysis of randomized controlled trials.

ABSTRACT:

Objective(s)

Several studies have assessed the effect of angiotensin II receptor blockers (ARBs) on peripheral endothelial dysfunction as measured by flow-mediated vasodilatation (FMD), a widely-used indicator for endothelial function. We conducted a meta-analysis to investigate the effect in comparison to placebo or no treatment and other antihypertensives.

Methods

MEDLINE, Cochrane library and EMBASE were searched to September 2013 for randomized controlled trials (RCTs) that assessed the effect of ARBs versus placebo or no treatment and other antihypertensives (angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), β-blockers, diuretics) by forearm FMD. Furthermore, we also use meta-regression to analyze the relationship between the endothelial

SUBMITTER: Li S 

PROVIDER: S-EPMC3940822 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature