Modeling the Drosophila gene cluster regulation network for muscle development.

ABSTRACT: The development of accurate and reliable dynamical modeling procedures that describe the time evolution of gene expression levels is a prerequisite to understanding and controlling the transcription process. We focused on data from DNA microarray time series for 20 Drosophila genes involved in muscle development during the embryonic stage. Genes with similar expression profiles were clustered on the basis of a translation-invariant and scale-invariant distance measure. The time evolution of these clusters was modeled using coupled differential equations. Three model structures involving a transcription term and a degradation term were tested. The parameters were identified in successive steps: network construction, parameter optimization, and parameter reduction. The solutions were evaluat

SUBMITTER: Haye A 

PROVIDER: S-EPMC3940846 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature