Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor.

ABSTRACT: The formation of signalling boundaries is one of the strategies employed by the Notch (N) pathway to give rise to two distinct signalling populations of cells. Unravelling the mechanisms involved in the regulation of these signalling boundaries is essential to understanding the role of N during development and diseases. The function of N in the segmentation of the Drosophila leg provides a good system to pursue these mechanisms at the molecular level. Transcriptional and post-transcriptional regulation of the N ligands, Serrate (Ser) and Delta (Dl) generates a signalling boundary that allows the directional activation of N in the distalmost part of the segment, the presumptive joint. A negative feedback loop between odd-skipped-related genes and the N pathway maintains this signalling boun

SUBMITTER: Pueyo JI 

PROVIDER: S-EPMC3940869 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature