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Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.

ABSTRACT: The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects.

SUBMITTER: Li J

PROVIDER: S-EPMC3940970 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.

Li Jinquan J Li Li L Chen Hanqing H Chang Qing Q Liu Xudong X Wu Yang Y Wei Chenxi C Li Rui R Kwan Joseph K C JK Yeung King Lun KL Xi Zhuge Z Lu Zhisong Z Yang Xu X

Scientific reports 20140304

The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate alle ...[more]

PMID: 24589727

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Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.

Publications

Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.

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