Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC3941036 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Liu Baoyu B Zhong Shi S Malecek Karolina K Johnson Laura A LA Rosenberg Steven A SA Zhu Cheng C Krogsgaard Michelle M
European journal of immunology 20131020 1
Two-dimensional (2D) kinetic analysis directly measures molecular interactions at cell-cell junctions, thereby incorporating inherent cellular effects. By comparison, three-dimensional (3D) analysis probes the intrinsic physical chemistry of interacting molecules isolated from the cell. To understand how T-cell tumor reactivity relates to 2D and 3D binding parameters and to directly compare them, we performed kinetic analyses of a panel of human T-cell receptors (TCRs) interacting with a melanom ...[more]