The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.

ABSTRACT: Alternative splicing and mRNA editing are known to contribute to transcriptome diversity. Although alternative splicing is pervasive and contributes to a variety of pathologies, including cancer, the genetic context for individual differences in isoform usage is still evolving. Similarly, although mRNA editing is ubiquitous and associated with important biological processes such as intracellular viral replication and cancer development, individual variations in mRNA editing and the genetic transmissibility of mRNA editing are equivocal. Here, we have used linkage analysis to show that both mRNA editing and alternative splicing are regulated by the macrophage genetic background and environmental cues. We show that distinct loci, potentially harboring variable splice factors, regulate the sp

SUBMITTER: Hassan MA 

PROVIDER: S-EPMC3941103 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature