Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones.

ABSTRACT: Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis. A route to this class of compound has been developed. Key steps include Noyori reduction (which establishes the stereochemistry of the product), ring-closing metathesis, and simple functional group conversions to provide a set of substituted 4-HCPs in either enantiomeric form.

SUBMITTER: Singh G 

PROVIDER: S-EPMC3941174 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature