Metabolic versatility in Haemophilus influenzae: a metabolomic and genomic analysis.

ABSTRACT: Haemophilus influenzae is a host adapted human pathogen known to contribute to a variety of acute and chronic diseases of the upper and lower respiratory tract as well as the middle ear. At the sites of infection as well as during growth as a commensal the environmental conditions encountered by H. influenzae will vary significantly, especially in terms of oxygen availability, however, the mechanisms by which the bacteria can adapt their metabolism to cope with such changes have not been studied in detail. Using targeted metabolomics the spectrum of metabolites produced during growth of H. influenzae on glucose in RPMI-based medium was found to change from acetate as the main product during aerobic growth to formate as the major product during anaerobic growth. This change in end-product i

SUBMITTER: Othman DS 

PROVIDER: S-EPMC3941224 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature