A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii.

ABSTRACT:

Background

Apicomplexans contain only a core set of factors involved in vesicular traffic. Yet these obligate intracellular parasites evolved a set of unique secretory organelles (micronemes, rhoptries, and dense granules) that are required for invasion and modulation of the host cell. Apicomplexa replicate by budding from or within a single mother cell, and secretory organelles are synthesized de novo at the final stage of division. To date, the molecular basis for their biogenesis is unknown.

Results

We demonstrate that the apicomplexan dynamin-related protein B (DrpB) belongs to an alveolate specific family of dynamins that is expanded in ciliates. DrpB accumulates in a cytoplasmic region close to the Golgi that breaks up during replication and reforms after assembly of t

SUBMITTER: Breinich MS 

PROVIDER: S-EPMC3941470 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature