Accuracy of computational cerebral aneurysm hemodynamics using patient-specific endovascular measurements.

ABSTRACT: Computational hemodynamic simulations of cerebral aneurysms have traditionally relied on stereotypical boundary conditions (such as blood flow velocity and blood pressure) derived from published values as patient-specific measurements are unavailable or difficult to collect. However, controversy persists over the necessity of incorporating such patient-specific conditions into computational analyses. We perform simulations using both endovascularly-derived patient-specific and typical literature-derived inflow and outflow boundary conditions. Detailed three-dimensional anatomical models of the cerebral vasculature are developed from rotational angiography data, and blood flow velocity and pressure are measured in situ by a dual-sensor pressure and velocity endovascular guidewire at multipl

SUBMITTER: McGah PM 

PROVIDER: S-EPMC3941739 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature