Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task.

ABSTRACT:

Objective

Youths with disruptive behavior disorders, including conduct disorder and oppositional defiant disorder, show major impairments in reinforcement-based decision making. However, the neural basis of these difficulties remains poorly understood. This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based functional MRI (fMRI).

Method

Participants were 38 community youths ages 10-18 (20 had disruptive behavior disorders, and 18 were healthy comparison youths). Model-based fMRI was used to assess the computational processes involved in decision making and feedback processing in the ventromedial prefrontal cortex, insula, and caudate.

Results

Youths with disrupt

SUBMITTER: White SF 

PROVIDER: S-EPMC3941772 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature