Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence.

ABSTRACT:

Background

Alcohol dependence is more common among men than among women. Potential explanations for this include the role of genes in sex chromosomes (X and Y). In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence.

Methods

Two thousand nine hundred and twenty-seven individuals in two independent cohorts were analyzed. The European-American male cohort (883 cases with alcohol dependence and 445 controls) served as the discovery cohort and the European-American female cohort (526 cases and 1073 controls) served as a contrast group. All individuals were genotyped on the Illumina Human 1M beadchip. Two thousand two hundred and twenty-four single nucleotide polymorphisms (S

SUBMITTER: Zuo L 

PROVIDER: S-EPMC3941913 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature