Lower ankle-brachial index is related to worse cognitive performance in old age.

ABSTRACT:

Objective

We aimed to study the associations between peripheral artery disease (PAD) and ankle-brachial index (ABI) and performance in a range of cognitive domains in nondemented elderly persons.

Methods

Data were collected within the Lothian Birth Cohort 1921 and 1936 studies. These are two narrow-age cohorts at age 87 (n = 170) and 73 (n = 748) years. ABI was analyzed as a dichotomous (PAD vs. no PAD) and a continuous measure. PAD was defined as having an ABI less than 0.90. Measures of nonverbal reasoning, verbal declarative memory, verbal fluency, working memory, and processing speed were administered. Both samples were screened for dementia.

Results

We observed no significant differences in cognitive performance between persons with or without PAD. However, highe

SUBMITTER: Laukka EJ 

PROVIDER: S-EPMC3942013 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature