On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei.

ABSTRACT:

Background

Although technical advances in genomics and proteomics research have yielded a better understanding of the coding capacity of a genome, one major challenge remaining is the identification of all expressed proteins, especially those less than 100 amino acids in length. Such information can be particularly relevant to human pathogens, such as Trypanosoma brucei, the causative agent of African trypanosomiasis, since it will provide further insight into the parasite biology and life cycle.

Results

Starting with 993 T. brucei transcripts, previously shown by RNA-Sequencing not to coincide with annotated coding sequences (CDS), homology searches revealed that 173 predicted short open reading frames in these transcripts are conserved across kinetoplastids with 13 also co

SUBMITTER: Ericson M 

PROVIDER: S-EPMC3942054 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature