The effects of levothyroxine replacement or suppressive therapy on health status, mood, and cognition.

ABSTRACT:

Context

TSH-suppressive doses of levothyroxine (L-T4) have adverse effects on bone and cardiac function, but it is unclear whether central nervous system function is also affected.

Objective

The aim of the study was to determine whether women receiving TSH-suppressive L-T4 doses have decrements in health status, mood, or cognitive function.

Design and setting

A cross-sectional comparison was made among three groups of women in an academic medical center research clinic.

Patients

Twenty-four women receiving chronic TSH-suppressive L-T4 doses, 35 women receiving chronic replacement L-T4 doses, and 20 untreated control women participated in the study.

Interventions

Subjects underwent testing at a single outpatient visit.

Main outcome measures

We meas

SUBMITTER: Samuels MH 

PROVIDER: S-EPMC3942231 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature