SNP rs8099917 in gene IL28B might be associated with risk of chronic infection by HCV but not with response to treatment.

ABSTRACT:

Aim

The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia.

Methods

A total of 75 individuals with chronic hepatitis C and 98 healthy individuals from both genders over 18 years old were assessed. DNA samples were collected from leukocytes and subjected to real-time polymerase chain reaction to genotype polymorphisms rs12979860 and rs8099917.

Results

Analysis of the allelic and genotypic frequencies of the investigated polymorphisms showed that both groups were in Hardy-Wei

SUBMITTER: da Silva Conde SR 

PROVIDER: S-EPMC3942284 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature